Animal Models of Diabetes
Frontiers in Research, 2nd Edition
Editor:  Eleazar Shafrir
 

Contents

	Updates and expands information on animal models accumulated in recent years.
	Addresses the findings on the pathogenesis of diabetes and its complications in relation to human disease
	Covers animal models of Type 1 and Type 2 diabetes, including new models of autoimmune diabetes
	Provides extensive references for further information on each model
	Contains a review on nutritionally induced diabetes in the gerbil Psammomys obesus

Description
As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

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The Senescence-Accelerated Mouse (SAM):
An Animal Model of Senscence, 1260
Edited By Yasuyuki Nomura, Department of Pharmacology, Graduate School of Pharmaceutical Science, Hokkaido University, Sapporo, Japan
Toshio Takeda, Professor Emeritus of Kyoto University, The Council for SAM Research, Research Institute for Production Development, Kyoto, Japan
Yasunobu Okuma, Associate Professor, Department of Pharmacology. Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan


Description
This volume represents a summary of reports on studies using the Senescence Accelerated Mouse, as presented at the 2nd International Conference on Senescence: The SAM Model, held from 21-23 July in Sapporo, Japan. Work on the SAM began in 1968 in the Department of Pathology, Chart Disease Research Institute (currently Field of Regeneration Control Institute for Frontier Medical Sciences) of Kyoto University. Since 1982, experiments on the SAM have been carried out in over 300 laboratories in Japan and other countries. Many emerging aspects of the SAM model were successfully dealt with at the first conference, which was held in 1994 in Kyoto. Dramatic progress in research on the SAM model has been made since. The focus of this conference was on findings obtained by using the SAM model and pertinent information was provided by investigators working on the SAM model together with comments for those who are about to embark on SAM-related investigations. Many excellent papers included in this issue offer new insights into the significance of the SAM as an animal model of aging.

 

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Animal Lectins - A Functional View                                               Coming Oct. 2008

Lectins are currently of interest in the research community because of their wide variety of properties and potential applications in pharmacology, immunology, and cancer therapy. Identifying lectins and their ligands is the particular focus of intense study. Featuring contributions from recognized experts, Animal Lectins: A Functional View presents up-to-date knowledge of the biological roles of animal lectins, including glycoprotein folding, sorting, and targeting; cell adhesion; embryogenesis; cell-cell interactions and signaling; as well as recognition and effector functions in innate immunity. This book also explores the structural basis of protein-carbohydrate interactions.

	Presents cutting-edge research on the biological functions of animal lectins
	Describes the structural basis of protein-carbohydrate interactions
	Discusses the functions of lectins in innate immunity
	Features contributions from recognized experts

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